Activation of PI3K-Akt pathway mediates antiapoptotic effects of -adrenergic agonist in airway eosinophils
نویسندگان
چکیده
Kentaro Machida, Hiromasa Inoue, Koichiro Matsumoto, Miyuki Tsuda, Satoru Fukuyama, Hiroshi Koto, Hisamichi Aizawa, Yasuko Kureishi, Nobuyuki Hara, and Yoichi Nakanishi Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka; First Department of Internal Medicine, Kurume University School of Medicine, Fukuoka; and First Department of Internal Medicine, Mie University School of Medicine, Mie, Japan
منابع مشابه
Activation of PI3K-Akt pathway mediates antiapoptotic effects of beta-adrenergic agonist in airway eosinophils.
beta-Adrenoceptor agonists reportedly decrease spontaneous apoptosis of peripheral blood eosinophils; however, its signaling pathway is unknown. Survival signals can be elicited by the activation of phosphatidylinositol 3-kinase (PI3K) and Akt, both of which are known to be potent regulators of apoptosis, and Akt in turn inactivates Forkhead transcription factors, including FKHR (Forkhead in rh...
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